WP-3 In vivo Tools

WP leaders: Peter Languth Johannes Gutenberg Universit├Ąt Mainz and Patricia Zane Sanofi

The objectives of WP3 are:

  • The collection of in vivo data regarding physiological characterization of the gastrointestinal tract and the behaviour of compounds and formulations, eg GI transit properties, regional absorption data and human GI fluid data.
  • The performance of mechanistic experiments to improve understanding of the gastrointestinal system.
  • Measurement of in vivo dissolution and comparison with data from in vitro experiments to obtain a better understanding of pharmaceutical effects on drug absorption

Advances in predictability of human oral absorption and systemic availability.