Orbito research hits Belgian newspapers

Taking a tablet with sparkling water may be a good alternative for a more expensive effervescent tablet. In a study by Jens Van Den Abeele, healthy human volunteers were asked to ingest a conventional paracetamol tablet with either tap or sparkling water, after which antroduodenal motility as well as intraluminal and systemic drug disposition were monitored as a function of time. Ingestion of sparkling water led to the occurrence of transient pressure events in the upper gastrointestinal tract for all volunteers, although the duration and frequency of the observed effect were subject to variability. Based on systemic drug disposition parameters, drug intake with sparkling water resulted in a trend towards faster and less variable absorption of paracetamol from the gastrointestinal tract.